It is known that smoking, chronic intoxication, cooling and frostbite of the extremities, disorders of tadalafil innervation due to chronic neuritis of the sciatic nerve, injuries of the limb, etc. predispose to a long-term spastic state of peripheral vessels. athlete's foot.

Secondth stage of obliterating endarteritis, all of the above phenomena are intensified, there are pains in the limbs while walking - intermittent claudication, which forces the patient to make frequent stops for rest. Pulsation on the arteries of the feet is difficult to determine or absent on one leg.

The ulcerative-necrotic stage of obliterating endarteritis corresponds to pain at rest (especially at night), atrophy of the muscles of the legs, swelling of the skin, and the formation of trophic ulcers on the feet and fingers. Lymphangitis, thrombophlebitis often join the ulcerative process. The pulsation of the arteries on the feet is not determined.

The onset of gangrene is usually associated with the action of external factors (wounds, skin cuts) or with an existing ulcer. The foot and fingers are more often affected, less often gangrene spreads to the tissues of the lower leg. The syndrome of toxemia that develops with gangrene forces one to resort to amputation of the limb.